caspase 14, apoptosis-related cysteine peptidase

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caspase 14, apoptosis-related cysteine peptidase

BackgroundCaspases are a family of cysteine proteases that are key mediators of programmed cell death or apoptosis.1 The precursor form of all caspases is composed of a prodomain and large and small catalytic subunits. The active forms of caspases are generated by several stimuli including ligand-receptor interactions, growth factor deprivation, and inhibitors of cellular functions. All known caspases require cleavage adjacent to aspartates to liberate one large and one small subunit, which associate into an a2b2 tetramer to form the active enzyme. Caspase-14 has a conserved active site pentapeptide, QACRG. However, no proteolytic or biological activities have been identified so far. Its high expression in embryonic tissues and limited expression in adult tissues suggests that it may have some role during ontogenesis.

SynonymsCASP14; caspase 14, apoptosis-related cysteine peptidase; caspase 14, apoptosis related cysteine protease; caspase-14; apoptosis related cysteine protease; MGC119078; MGC119079; MICE; CASP-14; apoptosis-related cysteine protease; caspase 14, apoptosis-rel

Recombinant Proteins

Cell & Tissue Lysates

Cat.# Product name Source (Host) Species Tag Price

CASP14-0417H Recombinant Human CASP14 Protein, GST-Tagged Wheat Germ Human GST +Inquiry

CASP14-1168H Recombinant Human CASP14, His tagged E. coli Human His +Inquiry

CASP14-470H Recombinant Human CASP14 Protein, His-tagged E. coli Human His +Inquiry

CASP14-2750M Recombinant Mouse CASP14 Protein Mammalian Cells Mouse His +Inquiry

Casp14-690M Recombinant Mouse Casp14 Protein, His/GST-tagged E. coli Mouse His/GST +Inquiry

Casp14-691M Recombinant Mouse Casp14 Protein, His/GST-tagged E. coli Mouse His/GST +Inquiry

Casp14-692R Recombinant Rat Casp14 Protein, His-tagged E. coli Rat His +Inquiry

CASP14-3803C Recombinant Chicken CASP14 Mammalian Cells Chicken His +Inquiry

Protein Function

CASP14 has several biochemical functions, for example, cysteine-type endopeptidase activity, cysteine-type endopeptidase activity involved in apoptotic signaling pathway, protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by CASP14 itself. We selected most functions CASP14 had, and list some proteins which have the same functions with CASP14. You can find most of the proteins on our site.

FunctionRelated Protein

Function cysteine-type endopeptidase activityRelated Protein CASP3B; USP48; USP10; USP43A; USP13; CTSC; CTSL2; CASPB; CTSS; USP19

Function cysteine-type endopeptidase activity involved in apoptotic signaling pathwayRelated Protein CASP9; CASP8L1; CASP2; CFLARA; CASP10; CASP8; CASP14; CFLAR

Function protein bindingRelated Protein GABARAP; COMMD6; TNIP2; ALX1; NR1H4; NFS1; ARNTL2; CDK15; IFT27; PAX2

Interacting Protein

CASP14 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with CASP14 here. Most of them are supplied by our site. Hope this information will be useful for your research of CASP14.


CASP14 Related Articles

Ashokkumar, C; Sun, Q; et al. Antithymocyte Globulin Facilitates Alloreactive T-cell Apoptosis by Means of Caspase-3: Potential Implications for Monitoring Rejection-Free Outcomes. TRANSPLANTATION 99:164-170(2015).

Younesi, V; Nejatollahi, F; et al. Induction of anti-proliferative and apoptotic effects by anti-IL-25 receptor single chain antibodies in breast cancer cells. INTERNATIONAL IMMUNOPHARMACOLOGY 23:624-632(2014).

posted in: apoptosis-related cysteine peptidase, caspase 14

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