caspase 3, apoptosis-related cysteine peptidase

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CASP3

caspase 3, apoptosis-related cysteine peptidase

BackgroundThis gene encodes a protein which is a member of the cysteine-aspartic acid protease (caspase) family. Sequential activation of caspases plays a central role in the execution-phase of cell apoptosis. Caspases exist as inactive proenzymes which undergo proteolytic processing at conserved aspartic residues to produce two subunits, large and small, that dimerize to form the active enzyme. This protein cleaves and activates caspases 6, 7 and 9, and the protein itself is processed by caspases 8, 9 and 10. It is the predominant caspase involved in the cleavage of amyloid-beta 4A precursor protein, which is associated with neuronal death in Alzheimer's disease. Alternative splicing of this gene results in two transcript variants that encode the same protein.

SynonymsCASP3; caspase 3, apoptosis-related cysteine peptidase; CPP32; SCA-1; CPP32B; Apopain; CPP-32; EC 3.4.22.56; Yama; procaspase3; Cysteine protease CPP32; PARP cleavage protease; SREBP cleavage activity 1; Yama protein; caspase 3, apoptosis-related cysteine protease

Recombinant Proteins

Cell & Tissue Lysates

Others

Cat.# Product name Source (Host) Species Tag Price

CASP3-0421H Recombinant Human CASP3 Protein, GST-Tagged Wheat Germ Human GST +Inquiry

CASP3-1642H Recombinant Human Caspase 3, Apoptosis-related Cysteine Peptidase E. coli Human N/A +Inquiry

Casp3-1641M Recombinant Mouse Caspase 3 E. coli Mouse N/A +Inquiry

Casp3-1644R Recombinant Rat Caspase 3 E. coli Rat N/A +Inquiry

CASP3-158H Recombinant Human CASP3 E. coli Human +Inquiry

CASP3-192H Recombinant Human CASP3, Met&His-tagged E. coli Human Met/His +Inquiry

CASP3-293H Recombinant Human CASP3 protein, His/MBP-tagged E. coli Human His/MBP +Inquiry

CASP3-334H Recombinant Human CASP3 protein, GST-tagged Wheat Germ Human GST +Inquiry

CASP3-342H Recombinant Human CASP3, His tagged E. coli Human His +Inquiry

CASP3-621H Recombinant Human CASP3 protein, His-tagged E. coli Human His +Inquiry

CASP3-622H Recombinant Human CASP3 protein, His & T7-tagged E. coli Human His/T7 +Inquiry

Casp3-1643M Recombinant Mouse Casp3 protein E. coli Mouse N/A +Inquiry

Casp3-623M Recombinant Mouse Casp3 protein, His-tagged E. coli Mouse His +Inquiry

CASP3-1145R Recombinant Rat CASP3 Protein Mammalian Cells Rat His +Inquiry

Casp3-624R Recombinant Rat Casp3 protein, His & T7-tagged E. coli Rat His/T7 +Inquiry

Casp3-625R Recombinant Rat Casp3 protein, His & T7-tagged E. coli Rat His/T7 +Inquiry

CASP3-362C Recombinant Cynomolgus CASP3 Protein, His-tagged Mammalian Cells Cynomolgus Monkey His +Inquiry

CASP3-6290C Recombinant Chicken CASP3 Mammalian Cells Chicken His +Inquiry

CASP3-36H Recombinant Human CASP3, His-tagged E. coli Human His +Inquiry

Casp3-748R Recombinant Rat Caspase 3, His-tagged E. coli Rat His +Inquiry

Involved Pathway

Casp3 involved in several pathways and played different roles in them. We selected most pathways Casp3 participated on our site, such as MAPK signaling pathway, p signaling pathway, Apoptosis, which may be useful for your reference. Also, other proteins which involved in the same pathway with Casp3 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway NamePathway Related Protein

MAPK signaling pathwayNF1; ECSIT; RPS6KA3A; PAK2A; HSPB1; PPM1B; MEF2CB; TGFBR1; FGF6B; MAP3K6

p signaling pathwayIGFBP3; SESN1; PERP; CCND3; SERPINB5; SESN2; LRDD; COP1; RPRM; BID

ApoptosisMAP3K14; H1F0; CASP10; IRAK1; CFLAR; Gzmg; TNFRSF10D; IL3; DFFA; ADD1

Natural killer cell mediated cytotoxicityITGAL; PIK3CB; ULBP3; PLCG2; HCST; MAPK1; FAS; HLA-G; ZAP70; CD48

TNF signaling pathwayCREB3L3; MAPK3; FOS; LIF; TNF; TRADD; MMP14; RELA; PIK3R5; MAPK13

Serotonergic synapseGNB3; KCND2; KCNN2; ALOX12; PLA2G4C; TRPC1; NRAS; SLC18A2; GNG12; PLCB4

Non-alcoholic fatty liver disease (NAFLD)UQCRB; INS; FAS; BID; PRKAA1; NDUFA12; NDUFB6; TGFB1; NDUFA4; SREBF1

Alzheimers diseaseEIF2AK3; COX4I1; ATP2A3; PPP3R2; UQCRC2; FADD; PSEN1; SDHC; NDUFB11; MAPK1

Parkinsons diseaseCASP9; COX7B; ATP5O; NDUFB8; ATP5H; SLC6A3; NDUFB10; NDUFV1; UBE2G1; PRKACA

Amyotrophic lateral sclerosis (ALS)GRIN1; CASP1; CYCS; NEFM; RAC1; CAT; MAPK12; MAP2K6; CCS; GRIN2C

Huntingtons diseaseDNALI1; DNAH5; CASP8; NDUFA12; GNAQ; NDUFB7; NDUFS5; NDUFA7; SDHD; REST

PertussisC3; SERPING1; NLRP3; IL6; MAPK8; CALM2; Casp3; MAPK11; NFKB1; ITGA5

LegionellosisRAB1A; C3; PYCARD; SAR1B; NFKB1; IL12A; ITGB2; BCL2L13; ITGB2L; CD14

ToxoplasmosisIFNGR1; GNAI1; PIK3CD; SOCS1; LAMA4; TRAF6; ALOX5; MAP2K3; CASP9; NOS2

AmoebiasisCOL5A1; IL1B2; AASS; TLR2; SERPINB10; PLCB3; NFKB1; SERPINB6; CD1d1; TGFB3

TuberculosisRAB7; FCGR1; ITGB2; ATP6V0D2; ATP6V1H; IL18; IL23; MAPK8; IFNA8; NFYA

Hepatitis BSMAD3; AKT1; BAD; IFNA8; PIK3R1; IFNA14; CREB3L3; PTEN; MMP9; NRAS

Herpes simplex infectionDDX58; SKP2; Casp3; C1QBP; SRSF7B; MCRS1; HNRPKL; PML; SRSF2B; BF2

Pathways in cancerRALBP1; FGF12; FZD7; LAMB2; TRAF3; VEGFC; TGFB2; GRB2; ROCK1; PLCB2

Viral carcinogenesisCCNA2; HIST1H2BE; MRPS18B; YWHAG; CCND1; SP100; H2-Q10; CASP8; HLA-B; RBPJ

Proteoglycans in cancerTGFB2; HSPG2; PIK3CD; TFAP4; MRAS; ELK1; FZD9; WNT11; ARAF; FAS

MicroRNAs in cancerWNT3; STAT3; APC; MARCKS; ERBB2; EP300; BMPR2; TNR; GLS; THBS1

Colorectal cancerSMAD3; AKT2; TCF7L2; TCF7; DCC; TRP53; TGFBR2; PIK3R3; RAC2; MAPK10

Viral myocarditisHLA-DQB1; CASP9; HLA-DRB4; HLA-DMA; RAC2; ICAM1; CD80; HLA-DOB; HLA-E; CXADR

Protein Function

Casp3 has several biochemical functions, for example, aspartic-type endopeptidase activity, cyclin-dependent protein serine/threonine kinase inhibitor activity, cysteine-type endopeptidase activity. Some of the functions are cooperated with other proteins, some of the functions could acted by Casp3 itself. We selected most functions Casp3 had, and list some proteins which have the same functions with Casp3. You can find most of the proteins on our site.

FunctionRelated Protein

Function aspartic-type endopeptidase activityRelated Protein PGA; NRIP3; Ren1; PGA4; PGA5; ASPRV1; NRIP2; NOTS; SPPL2; SPPL3

Function cyclin-dependent protein serine/threonine kinase inhibitor activityRelated Protein CDKN2D; KAT2B; Casp3; CDKN1A; CDKN1BB; CDKN2C; CDKN2B; CDKN1B; HEXIM2; CDKN2A

Function cysteine-type endopeptidase activityRelated Protein USP49; USP4; CTSS; USP17L5; CASP8; USP5; CTSBB; BLMH; CTSO; USP9X

Function cysteine-type endopeptidase activity involved in apoptotic processRelated Protein Casp3; CLC; CASP8

Function cysteine-type endopeptidase activity involved in execution phase of apoptosisRelated Protein CASP6L2; CASP3A; Casp3; CASP3B; CASP7; CASP6L1; CASP6

Function cysteine-type peptidase activityRelated Protein CAPN3; CTSL2; CTLA2B; OTUD7B; USP17L1P; Ctsl; DESI2; CAPN12; USP17L3; CTS7

Function death receptor bindingRelated Protein BID; MYD88; TMBIM1; TNFSF15; FADD; FEM1B; PRDM4; NOL3; PIDD1; CFLAR

Function hydrolase activityRelated Protein ABHD17B; DDHD1; RNASEL4; CAPN2A; CLCA5; OVCA2; G6PC3; ADPRM; ABCB1A; INPPL1B

Function peptidase activityRelated Protein AZU1; CAPN11; ELA3L; PCSK5B; CAPN2A; PRSS59.1; OTUD7A; TPP1; CASP9; DHH

Function phospholipase A2 activator activityRelated Protein Casp3; PLAA

Function protease bindingRelated Protein INS2; ITGA3; LDLR; UBC; ITGB1; RFFL; COMP; TIMP2; ADRM1; Serpina1c

Function protein bindingRelated Protein DDX39A; HESX1; TXNIP; NPBWR1; FAM134B; CLNK; GGNBP2; MYOD1; UBE2U; ZNRF1

Function protein complex bindingRelated Protein PAFAH1B1; PPP2R2A; STRN4; YWHAB; CDK5RAP1; SHANK1; PRMT5; NOG; CALCA; NSF

Interacting Protein

Casp3 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with Casp3 here. Most of them are supplied by our site. Hope this information will be useful for your research of Casp3.

posted in: apoptosis-related cysteine peptidase, caspase 3

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