alexchem

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Chiral Ligands

The syntheses of chiral ligands have evolved into a very dynamic, rapidly growing area of research, attracting an increasing number of chemists from various disciplines.

Computer-Aided Drug Design

Computer-aided drug design (CADD) is a widely used technology using computational tools and resources for the storage, management, analysis and modeling of compounds. It relies on digital...

chiral pool synthesis

Chiral pool synthesis is one of the simplest approaches for chiral synthesis. A chiral starting material is manipulated through successive reactions, often by achiral reagents, to obtain the desired...

Biotin Labeling

Biotin labeling is the process of covalently attaching biotin to a protein, nucleic acid, or other molecule. Biotin has the advantages of rapidity, specificity and low molecular weight MW24431...

Building Block Synthesis

BOC Sciences can provide various types of methods to help you synthesize building block, whatever group or chemical constitutions you want to introduce. We are expert at designing the routine and...

Bioconjugation

Bioconjugation is a set of techniques allowing site-specific creation of a covalent link between a biomolecule and an exogenous moiety that endow it with desirable properties. This novel hybrid...

Antibody Conjugate

BOC Sciences has unique R & D expertise to provide the highest quality custom antibody conjugation services of different sizes and reasonable prices in the industry. At the same time, we provide a...

Remdesivir - CAS 1809249-37-3

Remdesivir is a nucleoside analog and an antiviral drug with EC50 values of 74 nM for SARS-CoV and MERS-CoV in HAE cells, and 30 nM for murine hepatitis virus in delayed brain tumor cells.

ROR Inhibitor

ROR Inhibitor I RORγt-IN-1 is a potent, orally bioavailable RORγγ Inhibitor with pIC 50of 8.4 and >8.2 for RORγ FRET assay and Th17 assay. II RORγ-IN-1is a RORγ inhibitor extracted from patent...

PTEN Inhibitor

PTEN is a heavily studied lipid phosphatase and tumour suppressor. It metabolizes PtdIns(3,4,5)P3,the principal product of the class I PI3-Kinases and thus inhibits the activation of the...

Prostaglandin Receptor Inhibitor

Prostaglandin receptor, a sub-family of cell surface seven-transmembrane receptors, are the G-protein-coupled receptors. There are currently ten known prostaglandin receptors on various cell types.

NKCC Inhibitor

There are three kinds of NKCC co-transporter channel inhibitors: Bumetanide, Furosemide (Lasix) and Furosemide sodium. Bumetanide (Ro 10-6338; PF 1593) is an inhibitor with an IC50 of 0.6 uM...

PDHK Inhibitor

PDHK regulates the activity of this complex by an inactivating phosphorylation. This complex is responsible for catalysing the oxidative decarboxylation of pyruvate, an important regulatory step in...

NBC Inhibitor

Na+-HCO3- cotransporters (NBCs) share some of the functions of Na+-H+ exchangers (NHEs). They are also important regulators of intracellular pH homeostasis, and they are also involved in...

NAE Inhibitor

MLN4924, an adenosine sulfamate, is the first-in-class NAE inhibitor developed through an initial screening of chemical libraries and additional medicinal chemistry. MLN4924 was reported by the...

PARP inhibitor

PARP inhibitors are a group of pharmacological inhibitors of the enzyme poly ADP ribose polymerase (PARP). They are developed for multiple indications; the most important is the treatment of cancer...

ADC Cytotoxin

A major advance in ADC technology came with the utilization of such highly potent drugs as calicheamicins, maytansinoids, auristatins, and CC1065 analogs. This progress reflects an appreciation that...

Immune checkpoint inhibitors

Immune checkpoints are proteins in the immune system that either turn up a signal or turn down a signal. These proteins help keep immune responses in check and can keep T cells from killing cancer...

Fluorescent Labeling

The enzyme can be modified to contain reactive groups that react with other pre-activated small molecules and biomolecules having chemically reactive groups such as amines, thiols, carboxylates...

enantiomer separation

Chiral synthesis, is also called enantioselective synthesis, plays an essential role in the discovery of innovative drugs and materials and has been widely used in the development of pharmaceutical...

High throughput Screening

High throughput screening (HTS) technology is based on experimental methods at the molecular and cellular levels, using microplate format as an experimental tool carrier, performing an experimental...

Synthetic peptide

Peptides are central compounds in the pharmaceutical industry, providing both final medications and lead compounds for the preparation of peptidomimetic or non-peptidic pharmaceuticals. Therapeutic...

Stable Isotopes

BOC Sciences provides a full range of Custom Radiolabeled Chemical Synthesis services. We have an experienced radiochemistry team which can provide our customers with timely and costeffective...

Nucleotide Synthesis

Nucleotides are the building blocks of nucleic acids; they are composed of three subunit molecules: a nitrogenous base, a five-carbon sugar (ribose or deoxyribose), and at least one phosphate group...

Antibody Drug Conjugate

Antibody-drug conjugates (ADCs) are an important class of highly potent biopharmaceutical drugs, which are created by coupling a small molecule anticancer drug or a therapeutic agent to an antibody...

Building Block Synthesis

Building blocks are important intermediates for many drugs and have major significance in the discovery and synthesis of drugs. Many important substances and some significant effect of natural drugs...

Carbohydrate Synthesis

Carbohydrates, an important class of natural products, play a wide range of key roles in complex biological processes involving specific events in vital cellular recognition processes...

Chiral Auxiliary

Chiral auxiliary is a compound or unit that is temporarily added to organic synthesis in order to control the synthesis of stereochemistry. As the figure below shows, by adding the chiral auxiliary...

Enzyme Labeling

The enzyme can be modified to contain reactive groups that react with other pre-activated small molecules and biomolecules having chemically reactive groups such as amines, thiols, carboxylates...

Fragment Libraries

Application of Fragment Libraries As an efficient method to accelerate the process of drug discovery, fragment screening has been widely recognized in academic and commercial fields. The FBDD method...

Lead Optimization

Lead optimization is a diversified operation in drug discovery, in which the chemical structures of compounds or biologics are modified to improve target's specificity, selectivity, pharmacodynamics...

ADC Linker

The ADC linker that connects the cytotoxic drug to the mAb is a key determinant of ADC activity. These linkers covalently couple the cytotoxic drug to the antibody, producing an ADC that should be...

drug testing service

BOC Sciences provides general drug testing, i.e. analysis and purification services for the clients from discovery candidates to clinical trial chemicals. BOC Sciences analytical team provides the...

Fluorine compounds

Organic fluorine compounds have had a profound impact on the development of bioactive for the modern pharmaceuticals market. BOC Sciences has major skills and a high degree of expertise in the field...

Antibody drug Conjugates service

Antibody-drug Conjugates or ADCs consist of an antibody, a cytotoxic drug, and a linker that attaches the two. Such conjugates exhibit a broadly applicable method to increase the antitumor activity...

Isotope Labeling

Acommon application for isotope is isotopic labeling, the use of unusual isotopes as tracers or markers in chemical reactions. BOC Sciences provides wide range of services such as custom...

custom synthesis

Customers are also welcome to provide literature methods or their own synthetic routes in which all relevant information such as reaction time, solvent, temperature, analytic data, purification...

Eribulin - CAS 253128-41-5

Eribulin suppressed centromere dynamics at concentrations that arrest mitosis. At 60 nmol/L eribulin (2 x mitotic IC(50)), the relaxation rate was suppressed 21%, the time spent paused increased 67...

CFTR Inhibitor

CFTR is important in the determination of fluid flow, ion concentration and transepithelial salt transport. BOC Sciences can provide many CFTR inhibitor including VX-809 (Lumacaftor), CFTRinh172...

reaction intermediate

A pharmaceutical intermediate is an organic compound produced during steps in the synthesis of an API that must undergo further molecular change or processing before it becomes an API. It is a...

Fluorescent Probes

Fluorescent probes are single fluorophores or fluorophores covalently conjugated with biological molecules. The broad selection of fluorophores offers a wide range of applications in life science...

Checkpoint inhibitors

Immune checkpoints are proteins in the immune system that either turn up a signal or turn down a signal. These proteins help keep immune responses in check and can keep T cells from killing cancer...

NR1D2 Inhibitor

Rev-ErbA beta (Rev-erbβ) also known as NR1D2 (nuclear receptor subfamily 1, group D, member 2) is a protein that in humans is encoded by the NR1D2 gene.Rev-erbβ is a member of the Rev-ErbA family...

Penicillin-binding proteins Inhibitor

An overview of penicillin-binding proteins (PBPs) Penicillin-binding proteins (PBPs) are membrane proteins located on the bacterial cell membrane that can bind covalently to penicillin and...

Plant Growth Regulator Inhibitor

An Overview of Plant Growth Regulator Plant growth regulators are a class of pesticides used to regulate plant growth and development, including synthetic hormone analogues with similar physiological...

Potassium voltage-gated channel Inhibitor

Potassium voltage-gated channel(KCNA3) is a protein that in humans is encoded by the KCNA3 gene. It belongs to the delayed rectifier class, members of which allow nerve cells to efficiently...

Prostacyclin Receptor Inhibitor

Prostacyclin receptor is a receptor for prostacyclin (a prostaglandin that is also called prostaglandin I2, PGI2). Its HGNC name is prostaglandin I2 (prostacyclin) receptor (IP) (symbol PTGIR; older...

Sphingosine 1 Phosphate Receptor Inhibitor

The sphingosine-1-phosphate receptors are a class of G protein-coupled receptors that are targets of the lipid signalling molecule Sphingosine-1-phosphate (S1P). They are divided into five subtypes...

Sphingosine-1-phosphate receptor 1 Inhibitor

Sphingosine-1-phosphate receptor 1(S1PR1) is a protein that in humans is encoded by the S1PR1 gene. It is a G-protein-coupled receptor which binds the bioactive signaling molecule sphingosine...

Selective androgen receptor modulators Inhibitor

Selective androgen receptor modulators(SARMs) is a novel class of androgen receptor ligands. They are intended to have the same kind of effects as androgenic drugs like anabolic steroids but be much...

Superparamagnetic Iron Oxide Particles

Superparamagnetic iron oxide microbeads have broad applications in biomedicine, such as magnetic cell isolation and biomolecules purification, magnetic resonance imaging of diseased tissues, magnetic...

Small-molecule inhibitors

BOC Sciences has directed sincere efforts toward providing customers with high quality small-molecule inhibitors (inhibitors, agonists and modulators) with optimal prices. Most of our products can be...

Formulation Service

Pharmaceutical formulation is the process in which different chemical substances, including the active drug, are combined to produce a final medicinal product. Development of novel dosage forms such...

Virtual Screening

The general scheme of a Structure-Based Virtual Screening (SBVS) strategy starts with processing the 3D target structural information of pharmaceutical protein interested. The target structure can be...

Bioconjugation

Bioconjugation is the process of joining of biomolecules to other biomolecules, small molecules, and polymers by chemical or biological means to form a novel complex consisting of both molecules...

Metabolites

Metabolites are the products of enzyme-catalyzed reactions that occur naturally within cells. The term metabolite is usually used to describe small molecules, while broader application is often...

Drug Discovery

BOC Sciences' capabilities in drug discovery include: computational efforts on Modeling and Design ,Medicinal Chemistry efforts on library synthesis and SAR studies, Biological Sciences...

Cancer Immunotherapy

Immunotherapy, a type of cancer treatment designed to eradicate disseminated cancer by harnessing the potential of the immune system. Immunotherapy agents do not directly attack the tumour but...